Abstract: The aim of the present study was to evaluate the effect of DL-malic acid addition in Pelibuey finishing diet on average daily gain, carcass characteristics and non-carcass components. Sixteen (16) male lambs with a mean body weight of 27 ± 1.92 kg, were used in a 48-d feeding experiment. Animals were fed a high-energy diet containing corn stover, as the only forage source, with and without the DL-malic acid (MA) addition. Animals were assigned randomly in two treatments with eight lambs each: 1) Addition of 4 g of DL-malic acid per kg of feed and 2) Control (diet 1 without MA). Four male lambs of each treatment were harvested after feeding experiment to measure carcass characteristics and non-carcass components. Lambs fed with MA presented a larger (P<0.05) Longissimus lumborum muscle area. Nevertheless, there were no effects (P>0.05) of MA on daily average weight gain and non-carcass components weight. In conclusion, addition of 4 g DL-malic acid to a high-energy feed enhances muscle accretion, which improves carcass quality of finishing lambs.

Resumen: El objetivo del presente estudio fue evaluar el efecto de la adición de DL-ácido málico en dietas de borregos Pelibuey en finalización sobre ganancia diaria de peso, características de la canal y componentes que no son parte de la canal. Se utilizaron 16 corderos machos de 27 ± 1.92 kg de peso vivo durante los 48 d de la prueba de alimentación. Los animales fueron alimentados con una dieta alta en energía que contenía rastrojo de maíz, como la única fuente de forraje, con y sin DL-ácido málico (MA). Los animales fueron asignados al azar a uno de los dos tratamientos con 8 borregos cada uno: 1) 4 g de MA por kilogramo de alimento y 2) Control (sin MA). Cuatro borregos de cada tratamiento fueron sacrificados, después de la prueba de alimentación, para medir las características de la canal y los componentes que no son parte de la canal. Los borregos alimentados con MA presentaron una mayor (P<0.05) área del musculo Longissimus lumborum. Sin embargo, no hubo efecto (P>0.05) del MA sobre la ganancia diaria de peso y peso de los componentes que no son parte de la canal. En conclusión, la adición de 4 g de DL-ácido málico, en alimento con alto contenido energético, promueve el crecimiento muscular lo que mejora la calidad de la canal de los borregos en finalización.

RESUMEN La Enfermedad de Paget extramamaria de la vulva es una neoplasia poco frecuente que representa solo el 1% de los cánceres de vulva. Clínicamente, se caracteriza por una placa eritematosa, bien definida, con erosiones y ulceraciones. El síntoma más frecuente es el prurito. Esta clínica tan inespecífica puede retrasar el diagnóstico, además de inducir a tratamientos inadecuados. El diagnóstico se realiza con estudio histopatológico e inmunohistoquímica, la cual orienta si es primario de piel o metástasis de otro cáncer, usualmente genitourinario o gastrointestinal subyacente. Actualmente no hay guías clínicas de tratamiento, pero dentro de las opciones la más aceptada es la cirugía de Mohs. Otros tratamientos incluyen uso de imiquimod, láser CO2, quimioterapia tópica o local, radioterapia o terapia fotodinámica. Cuando se trata de una enfermedad de Paget extramamaria primaria, el pronóstico es excelente y la mayoría de los pacientes fallece por otra condición. En cuanto a la enfermedad invasora, tiene una mortalidad de 13-18% con sobrevida a 5 años de 72% (1)

RESUMO A abobrinha é uma das dez hortaliças mais cultivadas no Brasil. Possui alto valor nutricional e, por isso é utilizada como ingrediente principal na produção de tortas, doces e ração animal. Apesar da importância econômica e nutricional, poucos são os trabalhos envolvendo a adubação e propagação da cultura. Neste contexto, objetivou-se avaliar o efeito do húmus de minhoca no desenvolvimento de plantas jovens de abobrinha. O experimento foi realizado durante os meses de novembro de 2012 a janeiro de 2013, em casa de vegetação. O delineamento estatístico foi inteiramente casualizado, com seis tratamentos (0, 100, 200, 300, 400 e 1000 g de húmus de minhoca por vaso de 1,5 L) e quatro repetições. As plantas cultivadas em 1000 g de húmus de minhoca apresentaram maiores teores de massa seca da folha, caule e raiz. Pela análise de regressão, observou-se que a dosagem de 750 g foi a que permitiu os máximos valores de razão de área foliar e razão de peso foliar. Identificou-se relação positiva entre a proporção de húmus e a massa seca de folhas+caule, massa seca da raiz e a massa seca total. Os teores de clorofila a e b foram maiores em doses de 575 e 644 g, respectivamente. Assim sendo, o uso de húmus de minhoca favorece o desenvolvimento fisiológico de plantas jovens de abobrinha.

ABSTRACT Zucchini is one of the ten most important vegetable crops grown in Brazil. It has a high nutritional value, and is used as main ingredient of cakes, candies and animal food. Despite the economical and nutritional importance, few researches are available about its propagation and fertilization. The main objective of this work was to evaluate the effect of the earthworm humus on the development of young zucchini plants. The experiment was carried out in a greenhouse from November (2012) to January (2013) in a complete randomized design, with six doses (0, 100, 200, 300, 400 and 1000 g of earthworm humus per a 1,5 L pot) and four replications. The plants grown in 1000 g had higher levels of dry mass of leaf, stem and root. Regression analysis showed that the dosage of 750 g allowed the maximum values of leaf area ratio and leaf weight ratio variables. A positive relationship was identified between the proportion of humus and the dry mass of leaves + stem, root dry mass and total dry mass. a and b chlorophyll levels were higher at doses of 575 and 644 g, respectively. Therefore, the use of earthworm humus favors the physiological development of young zucchini plants.

Abstract: A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After 3 days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance. Histology characteristically reveals a dense, neutrophilic infiltrate with leucocitoclasis but without other signs of vasculitis. Lesions may resolve spontaneously or with RA treatment. This case illustrates an uncommon skin manifestation of active rheumatoid arthritis.

Abstract Erosive lichen planus is an uncommon variant of lichen planus. Chronic erosions of the soles, accompanied by intense and disabling pain, are some of its most characteristic manifestations. We present the case of a woman who developed oral and plantar erosive lichen planus associated with lichen planus pigmentosus and ungueal lichen planus that were diagnosed after several years. The patient failed to respond to multiple therapies requiring longstanding medication but remained refractory. Knowledge of the treatment options for erosive lichen planus is insufficient. Further research is required to clarify their effectiveness, ideally adopting an evidence-based methodology.

AbstractCoccidioidomycosis is a highly prevalent disease in the Western hemisphere. It is considered one of the most virulent primary fungal infections. Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected. Primary inoculation is rare. Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease. Knowledge of cutaneous clinical forms of this infection is important and very useful for establishing prompt diagnosis and treatment. The purpose of this article is to provide a review of this infection, emphasizing its cutaneous manifestations, diagnostic methods and current treatment.